書名 Thresholds of genotoxic carcinogens : from mechanisms to regulation / edited by Takehiko Nohmi, Shoji Fukushima
出版項 Amsterdam : Elsevier/Academic Press, c2016
book jacket
館藏地 索書號 條碼 處理狀態
 陽明大學書庫區  QZ203 T531 2016    30020100809492  在架上
稽核項 xiv, 210 p. : ill. ; 25 cm
內容 Qualitative and quantitative assessments on low-dose carcinogenicity of genotoxic hepatocarcinogens : dose-response for key events in rat hepatocarcinogenesis -- Thresholds for hepatocarcinogenicity of DNA-reactive compounds -- Interaction of low-dose radiation and chemicals in cancer risk -- Possible mechanisms underlying genotoxic thresholds : DNA repair and translesion DNA synthesis -- DNA repair and its influence on points of departure for alkylating agent genotoxicity -- The role of endogenous versus exogenous DNA damage in risk assessment -- Thresholds of toxicological concern for genotoxic impurities in pharmaceuticals -- Practical thresholds in the derivation of occupational exposure limits (OELs) for carcinogens -- Experimental design and statistical analysis of threshold studies -- Nrf2 as a possible determinant of the threshold for carcinogenesis -- Assessment of nongenotoxic mechanisms in carcinogenicity test of chemicals; Quinone, quinone imine, and quinone methide as examples -- Mode of action and assessment of human relevance for chemical-induced animal tumors
主題 Genetic toxicology
Carcinogenesis
Carcinogenesis
Carcinogens -- toxicity
DNA Damage
Dose-Response Relationship, Drug
Mutagenicity Tests
其他作者 Nohmi, Takehiko
Fukushima, Shoji
國際標準書號 9780128016633 (hbk.) : US$130.00